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SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
USERS' SCORE
Good
Based on 20 Reviews
8.1
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Calcium (elemental) (from 2,775 mg complex of Calcium Carbonate, Calcium Citrate, Calcium Ascorbate)
1 g (1,000 mg)
77%
Magnesium (elemental) (from 928 mg complex of Magnesium Oxide, Magnesium Citrate, Magnesium Ascorbate)
500 mg
119%
Top Medical Research Studies
7
Calcium's role in stenting assessed
A Revised Optical Coherence Tomography-Derived Calcium Score to Predict Stent Underexpansion in Severely Calcified Lesions.
Limited impact on heart disease
We explored how severe calcium buildup in arteries may affect the success of heart stenting procedures, specifically focusing on identifying which calcified lesions might risk underexpansion of stents. In a study of 250 cases where optical coherence tomography (OCT) helped guide stenting, only those not treated with specific preparation methods were included.
The key findings showed that a significant portion—about 20%—of the lesions displayed stent underexpansion. We also discovered that certain features of the calcium, such as an angle over 270 degrees and a substantial thickness, were connected to reduced stent expansion.
Although the study emphasized calcium's role in predicting stent outcomes, we noted that it didn’t isolate how calcium management impacts heart disease directly. Thus, while the revised calcium scoring system can be useful in assessing stent expansion risk, the benefits of calcium treatment on heart disease remain less clear.
The key findings showed that a significant portion—about 20%—of the lesions displayed stent underexpansion. We also discovered that certain features of the calcium, such as an angle over 270 degrees and a substantial thickness, were connected to reduced stent expansion.
Although the study emphasized calcium's role in predicting stent outcomes, we noted that it didn’t isolate how calcium management impacts heart disease directly. Thus, while the revised calcium scoring system can be useful in assessing stent expansion risk, the benefits of calcium treatment on heart disease remain less clear.
Read More
9
Mitochondrial calcium uptake and heart
Enhancement of mitochondrial calcium uptake is cardioprotective against maladaptive hypertrophy by retrograde signaling uptuning Akt.
MCU's role in heart health
We explored how enhancing mitochondrial calcium uptake can influence heart disease, particularly in the context of heart hypertrophy, a condition that can lead to heart failure. The study focused on the mitochondrial calcium uniporter (MCU), a protein responsible for transporting calcium into mitochondria.
By examining heart samples from humans and mice at different stages of hypertrophy, we found that MCU levels increased during the initial adaptive phase but decreased when heart failure occurred. This tells us that the body tries to cope with added stress before ultimately struggling.
Our experiments involved manipulating MCU levels in mice through viral techniques, allowing us to observe the effects during pressure overload, simulating conditions of heart disease. We noticed that reducing MCU led to faster deterioration of heart function and increased fibrosis, indicating a poorer health status. Conversely, boosting MCU seemed to help preserve heart function and maintain tissue health even under stress.
Importantly, we found that improved mitochondrial calcium uptake triggered protective signals involving reactive oxygen species and Akt activation within the heart cells. These findings suggest that enhancing calcium uptake could offer a potential therapeutic strategy against maladaptive heart hypertrophy and contribute to a healthier heart response under stress.
By examining heart samples from humans and mice at different stages of hypertrophy, we found that MCU levels increased during the initial adaptive phase but decreased when heart failure occurred. This tells us that the body tries to cope with added stress before ultimately struggling.
Our experiments involved manipulating MCU levels in mice through viral techniques, allowing us to observe the effects during pressure overload, simulating conditions of heart disease. We noticed that reducing MCU led to faster deterioration of heart function and increased fibrosis, indicating a poorer health status. Conversely, boosting MCU seemed to help preserve heart function and maintain tissue health even under stress.
Importantly, we found that improved mitochondrial calcium uptake triggered protective signals involving reactive oxygen species and Akt activation within the heart cells. These findings suggest that enhancing calcium uptake could offer a potential therapeutic strategy against maladaptive heart hypertrophy and contribute to a healthier heart response under stress.
Read More
8
Calcium scoring aids heart disease prevention
Effects of Combining Coronary Calcium Score With Treatment on Plaque Progression in Familial Coronary Artery Disease: A Randomized Clinical Trial.
Moderate relevance to calcium treatment
We conducted a randomized trial to see how combining coronary artery calcium (CAC) scoring with a prevention strategy could limit plaque progression in patients who have a family history of heart disease. The study involved participants aged 40 to 70 who were asymptomatic but had relatives with early-onset coronary artery disease (CAD).
For those who had a CAC score between 1 and 399, we randomized them into two groups: one followed a prevention plan informed by their CAC score, while the other received usual care. After three years, we measured the plaque volume through follow-up assessments to observe how each group fared in terms of plaque progression.
Remarkably, our findings indicated that using the CAC score alongside a primary prevention approach helped reduce harmful lipids in the blood and slowed the development of plaque compared to standard care. This suggests that the CAC score can play a vital role in informing and enhancing preventive measures for those at intermediate risk of heart disease.
For those who had a CAC score between 1 and 399, we randomized them into two groups: one followed a prevention plan informed by their CAC score, while the other received usual care. After three years, we measured the plaque volume through follow-up assessments to observe how each group fared in terms of plaque progression.
Remarkably, our findings indicated that using the CAC score alongside a primary prevention approach helped reduce harmful lipids in the blood and slowed the development of plaque compared to standard care. This suggests that the CAC score can play a vital role in informing and enhancing preventive measures for those at intermediate risk of heart disease.
Read More
Most Useful Reviews
9.5
Heart symptoms vanish
This magnesium supplement significantly improved my heart health; after just one to two weeks of use, symptoms of heart disease disappeared. It is well-tolerated without side effects when taken as instructed. Though the tablets are slightly large, I ordered more since women especially benefit from magnesium. I highly recommend it!
Read More
8.3
Better overall health
I recently bought these vitamins as they were frequently out of stock. Since starting them, my bone and muscle health have improved. Calcium and magnesium are vital for heart and nervous system health, and I feel more energetic. The capsules are easy to swallow and convenient. I recommend these vitamins for anyone aiming to maintain their health.
Read More
7
Muscle pain relief
This product is fantastic for elderly muscle pain, heart health, and those with insomnia. It helps me sleep better at night.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
9
Mitochondrial calcium uptake and heart
Enhancement of mitochondrial calcium uptake is cardioprotective against maladaptive hypertrophy by retrograde signaling uptuning Akt.
MCU's role in heart health
We explored how enhancing mitochondrial calcium uptake can influence heart disease, particularly in the context of heart hypertrophy, a condition that can lead to heart failure. The study focused on the mitochondrial calcium uniporter (MCU), a protein responsible for transporting calcium into mitochondria.
By examining heart samples from humans and mice at different stages of hypertrophy, we found that MCU levels increased during the initial adaptive phase but decreased when heart failure occurred. This tells us that the body tries to cope with added stress before ultimately struggling.
Our experiments involved manipulating MCU levels in mice through viral techniques, allowing us to observe the effects during pressure overload, simulating conditions of heart disease. We noticed that reducing MCU led to faster deterioration of heart function and increased fibrosis, indicating a poorer health status. Conversely, boosting MCU seemed to help preserve heart function and maintain tissue health even under stress.
Importantly, we found that improved mitochondrial calcium uptake triggered protective signals involving reactive oxygen species and Akt activation within the heart cells. These findings suggest that enhancing calcium uptake could offer a potential therapeutic strategy against maladaptive heart hypertrophy and contribute to a healthier heart response under stress.
By examining heart samples from humans and mice at different stages of hypertrophy, we found that MCU levels increased during the initial adaptive phase but decreased when heart failure occurred. This tells us that the body tries to cope with added stress before ultimately struggling.
Our experiments involved manipulating MCU levels in mice through viral techniques, allowing us to observe the effects during pressure overload, simulating conditions of heart disease. We noticed that reducing MCU led to faster deterioration of heart function and increased fibrosis, indicating a poorer health status. Conversely, boosting MCU seemed to help preserve heart function and maintain tissue health even under stress.
Importantly, we found that improved mitochondrial calcium uptake triggered protective signals involving reactive oxygen species and Akt activation within the heart cells. These findings suggest that enhancing calcium uptake could offer a potential therapeutic strategy against maladaptive heart hypertrophy and contribute to a healthier heart response under stress.
Read More
8
Calcium scoring aids heart disease prevention
Effects of Combining Coronary Calcium Score With Treatment on Plaque Progression in Familial Coronary Artery Disease: A Randomized Clinical Trial.
Moderate relevance to calcium treatment
We conducted a randomized trial to see how combining coronary artery calcium (CAC) scoring with a prevention strategy could limit plaque progression in patients who have a family history of heart disease. The study involved participants aged 40 to 70 who were asymptomatic but had relatives with early-onset coronary artery disease (CAD).
For those who had a CAC score between 1 and 399, we randomized them into two groups: one followed a prevention plan informed by their CAC score, while the other received usual care. After three years, we measured the plaque volume through follow-up assessments to observe how each group fared in terms of plaque progression.
Remarkably, our findings indicated that using the CAC score alongside a primary prevention approach helped reduce harmful lipids in the blood and slowed the development of plaque compared to standard care. This suggests that the CAC score can play a vital role in informing and enhancing preventive measures for those at intermediate risk of heart disease.
For those who had a CAC score between 1 and 399, we randomized them into two groups: one followed a prevention plan informed by their CAC score, while the other received usual care. After three years, we measured the plaque volume through follow-up assessments to observe how each group fared in terms of plaque progression.
Remarkably, our findings indicated that using the CAC score alongside a primary prevention approach helped reduce harmful lipids in the blood and slowed the development of plaque compared to standard care. This suggests that the CAC score can play a vital role in informing and enhancing preventive measures for those at intermediate risk of heart disease.
Read More
7
Calcium's role in stenting assessed
A Revised Optical Coherence Tomography-Derived Calcium Score to Predict Stent Underexpansion in Severely Calcified Lesions.
Limited impact on heart disease
We explored how severe calcium buildup in arteries may affect the success of heart stenting procedures, specifically focusing on identifying which calcified lesions might risk underexpansion of stents. In a study of 250 cases where optical coherence tomography (OCT) helped guide stenting, only those not treated with specific preparation methods were included.
The key findings showed that a significant portion—about 20%—of the lesions displayed stent underexpansion. We also discovered that certain features of the calcium, such as an angle over 270 degrees and a substantial thickness, were connected to reduced stent expansion.
Although the study emphasized calcium's role in predicting stent outcomes, we noted that it didn’t isolate how calcium management impacts heart disease directly. Thus, while the revised calcium scoring system can be useful in assessing stent expansion risk, the benefits of calcium treatment on heart disease remain less clear.
The key findings showed that a significant portion—about 20%—of the lesions displayed stent underexpansion. We also discovered that certain features of the calcium, such as an angle over 270 degrees and a substantial thickness, were connected to reduced stent expansion.
Although the study emphasized calcium's role in predicting stent outcomes, we noted that it didn’t isolate how calcium management impacts heart disease directly. Thus, while the revised calcium scoring system can be useful in assessing stent expansion risk, the benefits of calcium treatment on heart disease remain less clear.
Read More
User Reviews
USERS' SCORE
Good
Based on 20 Reviews
8.1
9.5
Reduced heart symptoms
I take magnesium and calcium together, which effectively calmed my nervous system and improved my heart health. I suffer from epilepsy and surgical menopause, leading to mood swings and depression, but since taking these vitamins, my symptoms have alleviated. My hair and nails have improved as well. The dosage is good, and it's natural, which is hard to find for such a price.
Read More
9.5
Heart symptoms vanish
This magnesium supplement significantly improved my heart health; after just one to two weeks of use, symptoms of heart disease disappeared. It is well-tolerated without side effects when taken as instructed. Though the tablets are slightly large, I ordered more since women especially benefit from magnesium. I highly recommend it!
Read More
9.5
Support for menopause
This calcium supplement is excellent and particularly beneficial for my mother during menopause as it strengthens her bones and mitigates heart disease risks. She feels much better taking it alongside vitamin D, as advised by our endocrinologist. The convenient packaging makes it easy to recommend.
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8.8
Heart disease management
Magnesium is an excellent mineral for relieving stress. It relaxes the arteries, lowers blood pressure, and aids the heart in pumping blood. It also helps regulate blood sugar, which is beneficial for those with heart disease. Many people lack magnesium. Remember, calcium is crucial for bones and impacts muscle contraction, including that of the heart. A deficiency can lead to cardiovascular issues, osteoporosis, and related concerns. Always consult your doctor before use.
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8.8
Heart disease improvement
Magnesium is the perfect anti-stress mineral that helps lower blood pressure and improves heart function. After taking it, I felt a notable improvement in my heart health, and the anxiety subsided. With my constant magnesium deficiency, this supplement truly aids in managing heart disease. I highly recommend it, especially as it works well with calcium. If you enjoyed this post, please like it!
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