Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.5
USERS' SCORE
Moderately Good
Based on 20 Reviews
7.4
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Calcium (elemental) (from 2,775 mg complex of Calcium Carbonate, Calcium Citrate, Calcium Ascorbate)
1 g (1,000 mg)
77%
Magnesium (elemental) (from 928 mg complex of Magnesium Oxide, Magnesium Citrate, Magnesium Ascorbate)
500 mg
119%
Top Medical Research Studies
7
We examined how magnesium supplements might influence heart failure and serious heart-related issues in diabetic patients.
In a study involving over 94,000 veterans, we found that those taking magnesium supplements experienced a lower risk of heart failure compared to nonusers. Specifically, 8.0% of supplement users developed heart failure, versus 9.7% of nonusers.
Furthermore, magnesium intake was linked to a reduced chance of major adverse cardiac events. However, it’s important to note that these findings need further investigation through randomized controlled trials.
In a study involving over 94,000 veterans, we found that those taking magnesium supplements experienced a lower risk of heart failure compared to nonusers. Specifically, 8.0% of supplement users developed heart failure, versus 9.7% of nonusers.
Furthermore, magnesium intake was linked to a reduced chance of major adverse cardiac events. However, it’s important to note that these findings need further investigation through randomized controlled trials.
Read More
9
We explored how magnesium supplementation might influence mortality rates in patients with heart failure and preserved ejection fraction (HFpEF). The study involved nearly 2,000 patients, with careful matching to ensure a fair comparison between those receiving magnesium and those who weren’t.
Interestingly, we found that magnesium intake was linked to a significant reduction in 28-day mortality rates. This effect was most notable in older adults, women, and patients with high blood pressure. Despite these positive findings, magnesium treatment did lead to longer hospital and ICU stays.
Overall, magnesium shows promise as a supportive treatment for HFpEF, but further investigation is necessary to better understand its benefits and implications.
Interestingly, we found that magnesium intake was linked to a significant reduction in 28-day mortality rates. This effect was most notable in older adults, women, and patients with high blood pressure. Despite these positive findings, magnesium treatment did lead to longer hospital and ICU stays.
Overall, magnesium shows promise as a supportive treatment for HFpEF, but further investigation is necessary to better understand its benefits and implications.
Read More
8
Magnesium levels and heart disease mortality
We examined the link between serum magnesium levels and the risk of death from heart failure, coronary heart disease, and stroke in patients with chronic kidney disease who don’t require dialysis. Over a decade, we followed 1,271 patients, noting that those with higher magnesium levels experienced significantly lower mortality rates from these conditions.
This suggests that maintaining adequate magnesium levels may help improve health outcomes for individuals with advanced kidney issues and an increased risk of cardiovascular problems.
This suggests that maintaining adequate magnesium levels may help improve health outcomes for individuals with advanced kidney issues and an increased risk of cardiovascular problems.
Read More
Most Useful Reviews
9
Heart symptoms vanish
1 people found this helpful
This magnesium supplement significantly improved my heart health; after just one to two weeks of use, symptoms of heart disease disappeared. It is well-tolerated without side effects when taken as instructed. Though the tablets are slightly large, I ordered more since women especially benefit from magnesium. I highly recommend it!
Read More
9
Better overall health
1 people found this helpful
I recently bought these vitamins as they were frequently out of stock. Since starting them, my bone and muscle health have improved. Calcium and magnesium are vital for heart and nervous system health, and I feel more energetic. The capsules are easy to swallow and convenient. I recommend these vitamins for anyone aiming to maintain their health.
Read More
9
Muscle pain relief
This product is fantastic for elderly muscle pain, heart health, and those with insomnia. It helps me sleep better at night.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.5
- All Researches
9
Mitochondrial calcium uptake and heart
We explored how enhancing mitochondrial calcium uptake can influence heart disease, particularly in the context of heart hypertrophy, a condition that can lead to heart failure. The study focused on the mitochondrial calcium uniporter (MCU), a protein responsible for transporting calcium into mitochondria.
By examining heart samples from humans and mice at different stages of hypertrophy, we found that MCU levels increased during the initial adaptive phase but decreased when heart failure occurred. This tells us that the body tries to cope with added stress before ultimately struggling.
Our experiments involved manipulating MCU levels in mice through viral techniques, allowing us to observe the effects during pressure overload, simulating conditions of heart disease. We noticed that reducing MCU led to faster deterioration of heart function and increased fibrosis, indicating a poorer health status. Conversely, boosting MCU seemed to help preserve heart function and maintain tissue health even under stress.
Importantly, we found that improved mitochondrial calcium uptake triggered protective signals involving reactive oxygen species and Akt activation within the heart cells. These findings suggest that enhancing calcium uptake could offer a potential therapeutic strategy against maladaptive heart hypertrophy and contribute to a healthier heart response under stress.
By examining heart samples from humans and mice at different stages of hypertrophy, we found that MCU levels increased during the initial adaptive phase but decreased when heart failure occurred. This tells us that the body tries to cope with added stress before ultimately struggling.
Our experiments involved manipulating MCU levels in mice through viral techniques, allowing us to observe the effects during pressure overload, simulating conditions of heart disease. We noticed that reducing MCU led to faster deterioration of heart function and increased fibrosis, indicating a poorer health status. Conversely, boosting MCU seemed to help preserve heart function and maintain tissue health even under stress.
Importantly, we found that improved mitochondrial calcium uptake triggered protective signals involving reactive oxygen species and Akt activation within the heart cells. These findings suggest that enhancing calcium uptake could offer a potential therapeutic strategy against maladaptive heart hypertrophy and contribute to a healthier heart response under stress.
Read More
9
We explored how magnesium supplementation might influence mortality rates in patients with heart failure and preserved ejection fraction (HFpEF). The study involved nearly 2,000 patients, with careful matching to ensure a fair comparison between those receiving magnesium and those who weren’t.
Interestingly, we found that magnesium intake was linked to a significant reduction in 28-day mortality rates. This effect was most notable in older adults, women, and patients with high blood pressure. Despite these positive findings, magnesium treatment did lead to longer hospital and ICU stays.
Overall, magnesium shows promise as a supportive treatment for HFpEF, but further investigation is necessary to better understand its benefits and implications.
Interestingly, we found that magnesium intake was linked to a significant reduction in 28-day mortality rates. This effect was most notable in older adults, women, and patients with high blood pressure. Despite these positive findings, magnesium treatment did lead to longer hospital and ICU stays.
Overall, magnesium shows promise as a supportive treatment for HFpEF, but further investigation is necessary to better understand its benefits and implications.
Read More
8
We conducted a randomized trial to see how combining coronary artery calcium (CAC) scoring with a prevention strategy could limit plaque progression in patients who have a family history of heart disease. The study involved participants aged 40 to 70 who were asymptomatic but had relatives with early-onset coronary artery disease (CAD).
For those who had a CAC score between 1 and 399, we randomized them into two groups: one followed a prevention plan informed by their CAC score, while the other received usual care. After three years, we measured the plaque volume through follow-up assessments to observe how each group fared in terms of plaque progression.
Remarkably, our findings indicated that using the CAC score alongside a primary prevention approach helped reduce harmful lipids in the blood and slowed the development of plaque compared to standard care. This suggests that the CAC score can play a vital role in informing and enhancing preventive measures for those at intermediate risk of heart disease.
For those who had a CAC score between 1 and 399, we randomized them into two groups: one followed a prevention plan informed by their CAC score, while the other received usual care. After three years, we measured the plaque volume through follow-up assessments to observe how each group fared in terms of plaque progression.
Remarkably, our findings indicated that using the CAC score alongside a primary prevention approach helped reduce harmful lipids in the blood and slowed the development of plaque compared to standard care. This suggests that the CAC score can play a vital role in informing and enhancing preventive measures for those at intermediate risk of heart disease.
Read More
8
Magnesium levels and heart disease mortality
We examined the link between serum magnesium levels and the risk of death from heart failure, coronary heart disease, and stroke in patients with chronic kidney disease who don’t require dialysis. Over a decade, we followed 1,271 patients, noting that those with higher magnesium levels experienced significantly lower mortality rates from these conditions.
This suggests that maintaining adequate magnesium levels may help improve health outcomes for individuals with advanced kidney issues and an increased risk of cardiovascular problems.
This suggests that maintaining adequate magnesium levels may help improve health outcomes for individuals with advanced kidney issues and an increased risk of cardiovascular problems.
Read More
8
Magnesium intake impacts heart disease risk
We explored the link between magnesium intake and heart disease risk in young adults, using a comprehensive study of U.S. adults aged 20 to 34. This cross-sectional research analyzed data from the National Health and Nutrition Examination Survey, examining dietary habits and various cardiovascular factors.
Our findings suggest that higher magnesium intake is associated with a lower risk of future cardiovascular issues and non-HDL cholesterol problems. This suggests that including magnesium-rich foods in our diets could promote heart health early in life.
Our findings suggest that higher magnesium intake is associated with a lower risk of future cardiovascular issues and non-HDL cholesterol problems. This suggests that including magnesium-rich foods in our diets could promote heart health early in life.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 20 Reviews
7.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Heart symptoms vanish
1 people found this helpful
This magnesium supplement significantly improved my heart health; after just one to two weeks of use, symptoms of heart disease disappeared. It is well-tolerated without side effects when taken as instructed. Though the tablets are slightly large, I ordered more since women especially benefit from magnesium. I highly recommend it!
Read More
9
Better overall health
1 people found this helpful
I recently bought these vitamins as they were frequently out of stock. Since starting them, my bone and muscle health have improved. Calcium and magnesium are vital for heart and nervous system health, and I feel more energetic. The capsules are easy to swallow and convenient. I recommend these vitamins for anyone aiming to maintain their health.
Read More
9
Muscle pain relief
This product is fantastic for elderly muscle pain, heart health, and those with insomnia. It helps me sleep better at night.
Read More
9
Reduced heart symptoms
8 people found this helpful
I take magnesium and calcium together, which effectively calmed my nervous system and improved my heart health. I suffer from epilepsy and surgical menopause, leading to mood swings and depression, but since taking these vitamins, my symptoms have alleviated. My hair and nails have improved as well. The dosage is good, and it's natural, which is hard to find for such a price.
Read More
9
Support for menopause
1 people found this helpful
This calcium supplement is excellent and particularly beneficial for my mother during menopause as it strengthens her bones and mitigates heart disease risks. She feels much better taking it alongside vitamin D, as advised by our endocrinologist. The convenient packaging makes it easy to recommend.
Read More
Frequently Asked Questions
9
Heart symptoms vanish
1 people found this helpful
This magnesium supplement significantly improved my heart health; after just one to two weeks of use, symptoms of heart disease disappeared. It is well-tolerated without side effects when taken as instructed. Though the tablets are slightly large, I ordered more since women especially benefit from magnesium. I highly recommend it!
9
Reduced heart symptoms
8 people found this helpful
I take magnesium and calcium together, which effectively calmed my nervous system and improved my heart health. I suffer from epilepsy and surgical menopause, leading to mood swings and depression, but since taking these vitamins, my symptoms have alleviated. My hair and nails have improved as well. The dosage is good, and it's natural, which is hard to find for such a price.
7.5
Improved heart function
1 people found this helpful
At first, I experienced some pains and malaise during the reception, but eventually, everything stabilised, and my heart and nerve indicators improved. I noticed no side effects.
0
Stopped due to symptoms
After two weeks, my heart began pounding, so I stopped taking it. I felt normal again after stopping, but the dosage seemed quite high, which I didn't like.
7.5
Essential supplementation
1 people found this helpful
For calcium supplementation, vitamin D3 opens up the body, while K2 directs calcium to the right places. This combination is excellent for heart health, and I really like it.
7.5
Heart disease management
107 people found this helpful
Magnesium is an excellent mineral for relieving stress. It relaxes the arteries, lowers blood pressure, and aids the heart in pumping blood. It also helps regulate blood sugar, which is beneficial for those with heart disease. Many people lack magnesium. Remember, calcium is crucial for bones and impacts muscle contraction, including that of the heart. A deficiency can lead to cardiovascular issues, osteoporosis, and related concerns. Always consult your doctor before use.
0
Caution advised
1 people found this helpful
Combining calcium with other nutrients in one capsule seems a marketing trick. It might do more harm than good, particularly for those with heart disease.
7
We examined how magnesium supplements might influence heart failure and serious heart-related issues in diabetic patients.
In a study involving over 94,000 veterans, we found that those taking magnesium supplements experienced a lower risk of heart failure compared to nonusers. Specifically, 8.0% of supplement users developed heart failure, versus 9.7% of nonusers.
Furthermore, magnesium intake was linked to a reduced chance of major adverse cardiac events. However, it’s important to note that these findings need further investigation through randomized controlled trials.
In a study involving over 94,000 veterans, we found that those taking magnesium supplements experienced a lower risk of heart failure compared to nonusers. Specifically, 8.0% of supplement users developed heart failure, versus 9.7% of nonusers.
Furthermore, magnesium intake was linked to a reduced chance of major adverse cardiac events. However, it’s important to note that these findings need further investigation through randomized controlled trials.
8
Magnesium levels and heart disease mortality
We examined the link between serum magnesium levels and the risk of death from heart failure, coronary heart disease, and stroke in patients with chronic kidney disease who don’t require dialysis. Over a decade, we followed 1,271 patients, noting that those with higher magnesium levels experienced significantly lower mortality rates from these conditions.
This suggests that maintaining adequate magnesium levels may help improve health outcomes for individuals with advanced kidney issues and an increased risk of cardiovascular problems.
This suggests that maintaining adequate magnesium levels may help improve health outcomes for individuals with advanced kidney issues and an increased risk of cardiovascular problems.
7
We investigated the effect of magnesium and calcium on blood sugar levels in 11,934 patients with coronary artery disease. Our findings indicated that higher serum magnesium levels and a favorable magnesium to calcium ratio were associated with lower abnormal HbA1c levels, which reflect better blood sugar management. In contrast, calcium showed no significant association with HbA1c levels. Importantly, we found no evidence that inflammation played a role in this relationship. Overall, magnesium might be beneficial for maintaining healthy blood sugar levels in those with heart disease.
8
Magnesium-rich diet linked to heart health
We examined how a magnesium-rich diet influences heart disease risk by analyzing over 15,000 adults in the Atherosclerosis Risk in Communities study.
Participants were tracked for more than 30 years, and those who enjoyed more magnesium-dense foods, like whole grains and nuts, showed a lower risk for cardiovascular and coronary heart diseases.
However, we found no significant relationship between magnesium-rich diets and ischaemic stroke incidence, indicating that the benefits might not extend to all heart-related conditions.
Participants were tracked for more than 30 years, and those who enjoyed more magnesium-dense foods, like whole grains and nuts, showed a lower risk for cardiovascular and coronary heart diseases.
However, we found no significant relationship between magnesium-rich diets and ischaemic stroke incidence, indicating that the benefits might not extend to all heart-related conditions.
References
- Sato T, Matsumura M, Yamamoto K, Sugizaki Y, Shlofmitz E, et al. A Revised Optical Coherence Tomography-Derived Calcium Score to Predict Stent Underexpansion in Severely Calcified Lesions. JACC Cardiovasc Interv. 2025;18:622. doi:10.1016/j.jcin.2024.12.001
- Zaglia T, Campo A, Moro N, Di Mauro V, Borile G, et al. Enhancement of mitochondrial calcium uptake is cardioprotective against maladaptive hypertrophy by retrograde signaling uptuning Akt. Proc Natl Acad Sci U S A. 2025;122:e2402639122. doi:10.1073/pnas.2402639122
- Nerlekar N, Vasanthakumar SA, Whitmore K, Soh CH, Chan J, et al. Effects of Combining Coronary Calcium Score With Treatment on Plaque Progression in Familial Coronary Artery Disease: A Randomized Clinical Trial. JAMA. 2025. doi:10.1001/jama.2025.0584
- Cheng Y, Zullo AR, Yin Y, Shao Y, Liu S, et al. Nonprescription Magnesium Supplement Use and Risk of Heart Failure in Patients With Diabetes: A Target Trial Emulation. J Am Heart Assoc. 2025;14:e038870. doi:10.1161/JAHA.124.038870
- Moyano-Peregrin C, Rodelo-Haad C, Martín-Malo A, Muñoz-Castañeda JR, Ojeda R, et al. Upper normal serum magnesium is associated with a reduction in incident death from fatal heart failure, coronary heart disease and stroke in non-dialysis patients with CKD stages 4 and 5. Clin Kidney J. 2025;18:sfae390. doi:10.1093/ckj/sfae390
- Dong H, Lu N, Wang J, Hu P. Serum magnesium, not calcium, is inversely associated with abnormal HbA1c concentrations in adults with coronary artery disease. Asia Pac J Clin Nutr. 2025;34:104. doi:10.6133/apjcn.202502_34(1).0010
- Song L, Ying J, Li M, Ying L, Zhao C. Propensity score matched cohort study on magnesium supplementation and mortality in critically ill patients with HFpEF. Sci Rep. 2025;15:1944. doi:10.1038/s41598-025-85931-1
- Sun L, Du J. Magnesium status, serum vitamin D concentration and mortality among congestive heart failure patients: a cohort study from NHANES 2007-2018. Magnes Res. 2024;37:61. doi:10.1684/mrh.2024.0528
- Song Q, Song L, Liu H, Tan H, Yang B, et al. Association of magnesium intake with predicted atherosclerotic lesions and cardiovascular risk in young adults based on PDAY score: a cross-sectional study. BMC Public Health. 2024;24:3232. doi:10.1186/s12889-024-20785-2
- Behers BJ, Behers BM, Stephenson-Moe CA, Vargas IA, Meng Z, et al. Magnesium and Potassium Supplementation for Systolic Blood Pressure Reduction in the General Normotensive Population: A Systematic Review and Subgroup Meta-Analysis for Optimal Dosage and Treatment Length. Nutrients. 2024;16. doi:10.3390/nu16213617
- Jiang Y, Luo B, Chen Y, Lu W, Peng Y, et al. Serum calcium-magnesium ratio at admission predicts adverse outcomes in patients with acute coronary syndrome. PLoS One. 2024;19:e0313352. doi:10.1371/journal.pone.0313352
- Wyss C, Gündling PW, Kostev K. Real world effectiveness of Hawthorn special extract WS 1442 in a retrospective cohort study from Germany. Sci Rep. 2024;14:22986. doi:10.1038/s41598-024-74325-4
- Seguchi M, Aytekin A, Xhepa E, Haude M, Wlodarczak A, et al. Vascular response following implantation of the third-generation drug-eluting resorbable coronary magnesium scaffold: an intravascular imaging analysis of the BIOMAG-I first-in-human study. EuroIntervention. 2024;20:e1173. doi:10.4244/EIJ-D-24-00055
- Zhang J, Chen Z, Rao L, He Y. Coronary bioresorbable metallic stents: Advancements and future perspectives. J Cardiol. 2025;85:69. doi:10.1016/j.jjcc.2024.08.003
- Copp KL, Steffen LM, Yi SY, Lutsey PL, Rebholz CM, et al. Magnesium-rich diet score is inversely associated with incident cardiovascular disease: the Atherosclerosis Risk in Communities (ARIC) study. Eur J Prev Cardiol. 2025;32:386. doi:10.1093/eurjpc/zwae251
- Zhuang J, Zhang Q, Wang H, Su PH, Chen PY. Association between short-term changes in serum magnesium and in-hospital mortality following acute myocardial infarction: a cohort study based on the MIMIC database. Magnes Res. 2024;37:45. doi:10.1684/mrh.2024.0517
- Fruh V, Babalola T, Sears C, Wellenius GA, Webster TF, et al. Dietary Minerals and Incident Cardiovascular Outcomes among Never-Smokers in a Danish Case-Cohort Study. Int J Environ Res Public Health. 2024;21. doi:10.3390/ijerph21070932
- Tao J, Wang J, Peng H, Yuan Y, Lai H, et al. Association between serum phosphate, magnesium, calcium and aortic valve sclerosis: a propensity score-matched case-control study. Acta Cardiol. 2024;79:522. doi:10.1080/00015385.2024.2379682
- Zhang J, Sun D, Guo Y, Tong J, Liu Q, et al. Targeted delivery of black phosphorus nanosheets by ROS responsive complex hydrogel based on angiogenesis and antioxidant promotes myocardial infarction repair. J Nanobiotechnology. 2024;22:433. doi:10.1186/s12951-024-02685-0
